Goat Secondary Antibodies
Cayman Chemical Aminooxyacetic Acid (hydrochloride), Purity: ≥95%, CAS: 2921-14-4, 1 g
A GABA-T inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain; inhibits CBS and CSE (IC50s = 8.5 and 1.1 μM, respectively); decreases GABA-T activity and increases GABA levels in all regions of rat brain at 100 mg/kg; decreases GABA-T activity and increases GABA in mouse brain at 13 mg/kg; inhibits 3-mercaptopropionic acid-, strychnine-, and pentetrazole-induced seizures in mice (ED50s = 53, 130, and 85 mg/kg, respectively); exhibits neurotoxicity in the chimney test (ED50 = 62 mg/kg) and is lethal (LD50 = 105 mg/kg) to mice
Cayman Chemical 1-Aminoguanosine-3',5'-monophosphate (sodium salt), Purity: ≥95%, CAS: 1380911-23-8, 1.9 mg
A substrate for cGMP-dependent protein kinase
Cayman Chemical C12 NBD 3sulfo Galactosylce
A fluorescently tagged sphingolipid; tagged with C12 NBD
Cayman Chemical Ticarcillin (sodium salt), Purity: ≥95% (mixture of diastereomers), CAS: 4697-14-7, 10 g
A semi-synthetic β-lactam antibiotic; active against P. aeruginosa, E. coli, P. mirabilis, P. rettgeri, and K. aerogenes (MICs = 4-125 μg/ml); reduces P. aeruginosa colony count in rabbit eye at 2.5 mg/eye
Cayman Chemical 1-Myristoyl-2-hydroxy-sn-glycero-3-PG (sodium salt), Purity: ≥95% (9:1 mixture of 1-acyl and 2-acyl), CAS: 326495-21-0, 500 mg
A lysophospholipid; has been used in the generation of micelles, liposomes, and other types of artificial membranes, including lipid-based drug carrier systems
Cayman Chemical Flubendazole, Purity: ≥95%, CAS: 31430-15-6, 50 g
A benzimidazole carbamate anthelmintic; completely eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model at 5 and 50 mg/kg per day, respectively; inhibits mammalian tubulin polymerization (IC50 = 2.5 µM); inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50 = 0.17 µM); inhibits the proliferation of BT-549, SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells (IC50s = 0.72, 1.51, 1.75, and 5.51 µM, respectively); reduces tumor growth in an MDA-MB-231 mouse xenograft model at 25 mg/kg
Cayman Chemical Cefalothin (sodium salt), Purity: ≥98%, CAS: 58-71-9, 250 mg
A β-lactam cephalosporin antibiotic; inhibits the growth of various Gram-positive and Gram-negative bacteria, including several strains of S. pyogenes, S. aureus, C. tetani, N. gonorrhoeae, Salmonella, and Shigella (MICs = 0.1-0.2, 0.312-0.625, 0.078, 1.25, 1.56-6.25, and 3.12-12.5 μg/ml, respectively); binds to E. coli PBPs (IC50s = S. pyogenes, D. pneumoniae, and S. aureus
Cayman Chemical PACAP6-38humnchIcken500ug
A PACAP receptor antagonist (IC50s = 30, 600, and 40 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors ); binds to PACAP receptors in rat brain membrane (IC50 = 39.14 nM) and to SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 2.9, 129, and 227 nM, respectively); inhibits vasodilation of pial arterioles induced by PACAP-38 in newborn pigs (10 μM); blocks CARTp-induced decreases in food intake and reduction in body weight in rats (0.3-3 mol per animal, i.c.v.)
Cayman Chemical Dodecylphosphocholine-d38, Purity: ≥99% deuterated forms (d1-d38), CAS: 130890-78-7, 250 mg
An internal standard for the quantification of dodecylphosphocholine by GC- or LC-MS
Cayman Chemical Sinapic Acid, Purity: ≥98%, CAS: 530-59-6, 5 g
A phenylpropanoid hydroxycinnamic acid with diverse biological activities; inhibits collagen-induced human platelet aggregation (IC50 = 1.03 mM); scavenges DPPH and ABTS free radicals (IC50s = 8.3 and 5.4 μg/ml, respectively); reduces colony formation of SW480 human colon carcinoma cells by 4-fold at 200 μM; inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively); increases the time spent in the open arms of the elevated plus maze in mice at 4 mg/kg; commonly used as a matrix in protein mass spectrometry
Cayman Chemical 1,2-Dierucoyl-sn-glycero-3-PC, Purity: ≥98%, CAS: 51779-95-4, 50 mg
A phospholipid; has been used in the study of lipid membranes and to determine the effect of long-chain phospholipids on the secondary structure of hIAPP
Cayman Chemical Chlorotoluron, Purity: ≥98%, CAS: 15545-48-9, 1 g
A phenylurea herbicide; has been used to control growth of broad-leaved weeds in winter wheat, rye, barley, and triticale crops; genotoxic, inducing formation of chromosome aberrations and SCE in a concentration-dependent manner in CHEL liver epithelial cells; induces testicular anaplasia as well as looseness and incrassation to the basement membrane that destroys the blood-testis barrier, increases SOD activity, and degrades mitochondria in mice (625-5,000 mg/kg); reduces food intake and body weight and induces hemolytic anemia, hemosiderosis of the spleen, and brown atrophy in dogs (9,200 ppm)
Cayman Chemical Dapansutrile, Purity: ≥98%, CAS: 54863-37-5, 250 mg
An NLRP3 inflammasome inhibitor; inhibits the release of IL-1β and decreases caspase-1 levels in LPS-stimulated J774A.1 murine macrophages, HMDMs, and primary human blood neutrophils; selective for NLRP3 over NLRP4 and AIM2 inflammasomes at concentrations up to 100 μM; inhibits ASC oligomerization and NLRP3 association with caspase-1 and ASC in LPS- and nigericin-stimulated J774A.1 cells; reduces MPO, CXCL1, and IL-6 levels in peritoneal fluid as well as IL-1β levels in liver, lung, spleen, and skeletal muscle in a mouse model of LPS-induced systemic inflammation; increases markers of oxidative metabolism in muscle in mouse model of LPS-induced systemic inflammation; reduces IL-1β release in blood monocytes isolated from patients with CAPS
Cayman Chemical Sinigrin (hydrate), Purity: ≥95%, 500 mg
A glucosinolate; inhibits NLRP3 inflammasome activation in ATP-stimulated, LPS-primed RAW 264.7 cells in a concentration-dependent manner; reduces LPS-induced NO and PGE2 production, as well as NF-κB activation, in RAW 264.7 cells; induces cell cycle arrest at the G0/G1 phase in HepG2 hepatocellular carcinoma cells at 0.1 and 0.5 mM; increases in renal glomerular basement membrane thickness, as well as increases in systolic and diastolic blood pressure, in a rat model of angiotensin II-induced hypertension
Cayman Chemical Pantoprazole, Purity: ≥98%, CAS: 102625-70-7, 250 mg
A proton pump inhibitor; inhibits H+/K+-ATPase activity in porcine gastric membrane vesicles (IC50 = 6.8 µM); reduces basal gastric acid secretion in pylorus-ligated rats (ED50 = 1.3 mg/kg); inhibits mepirizole-induced increases in gastric acid secretion in an anesthetized rat model of gastric fistula (ED50 = 0.8 mg/kg); inhibits formation of mepirizole-induced duodenal lesions in rats (ED50 = 0.5 mg/kg)